Meet the Group



Principal investigator


Lisa Tucker-Kellogg

Lisa TUCKER-KELLOGG | Lisa.Tucker-Kellogg@duke-nus.edu.sg
Lisa Tucker-Kellogg moved to the Duke-NUS Graduate Medical School in 2014, to join the Centre for Computational Biology and the Programme in Cancer and Stem Cell Biology. Previously she was an independent postdoctoral fellow at the Mechanobiology Institute and a recipient of the Lee Kuan Yew Postdoctoral Fellowship at the NUS School of Computing. She completed her PhD in computational structural biology at MIT under Tomas Lozano-Perez, Carl Pabo, and Bruce Tidor. She completed her Bachelor's degree in Math and Computer Science summa cum laude at Yale, where she won the A.D. Stanley and the DeForest Prizes in Pure and Applied Mathematics.


Members



Narendra Suhas Jagannathan

Narendra Suhas JAGANNATHAN | suhas@duke-nus.edu.sg
Suhas is a postdoctoral fellow in the lab, coming from the Singapore-MIT Alliance - Computational and systems biology programme. His simulations have shown how robust outcomes can arise from stochastic effects, and he is currently modeling the metabolic differences between M1 and M2 macrophages.


Julia Jenkins

Julia JENKINS | julia.jenkins@duke-nus.edu.sg
Julia is a postdoctoral fellow from the UK who worked previously on experimental studies of thrombosis. She is currently working on a cell culture model of pressure ulcer injury in differentiated C2C12 cells, testing model-based predictions of potential treatment strategies.


TAM Zhiyang

TAM Zhiyang | zhiyang@smart.mit.edu
Zhiyang is a postdoctoral fellow at the BioSyM Centre of the Singapore-MIT Alliance for Research and Technology, jointly supervised by Peter T. So. He received his Ph.D. from ETH Zurich under Rudi Gunawan. Zhiyang's research designs biologically relevant features for image analysis, builds computational models to simulate dynamic morphological change, and adapts methods of statistical machine learning for interpretation of spatiotemporal imaging data.


Akila Surendran

Akila SURENDRAN |
Akila is finishing some final publications of her doctoral degree in the Singapore-MIT Alliance - Computational and systems biology programme. Her thesis investigated the interplay between RhoA and nitric oxide in regulating cellular tension, and the role of nitric oxide in epithelial migration and epithelial-mesenchymal transition. She completed her undergraduate degree in Biotechnology in Anna University, India.


ALUMNI



NimTriHieu

NIM Tri Hieu | nimtrihieu11{at}nus.edu.sg
Nim Tri Hieu completed his high school in Vietnam before joining NTU for undergraduate study in Computer Science. For his doctoral work, he worked on parameter estimation and he modeled the dynamics of Akt activation. He is currently working with Felix Margadant on image analysis.
Keywords: mathematical modeling, cell signaling, reactive oxygen species, cancer, high-performance computing, multiprocessor parallelization, CUDA programming, web service, cloud computing, 3D visualization.


PANG Long ("Joshua") | pangnimo@gmail.com
Joshua is an undergraduate researcher studying Rho/Rac signaling during cell spreading. He is focusing on the oscillating pattern found during the protrusion and retraction of cell lamellipodial edges.


 

Shi Yuan

SHI Yuan
Shi Yuan pursued her doctoral degree in the Computational System Biology programme of the Singapore-MIT Alliance from 2007-2012. She got her Master's degree in the field of software engineering and technology in 2006 from Wuhan University, China.
Keywords: apoptosis, reactive oxygen species, cancer, combination therapy, pathway modeling, TRAIL, LY303511.


Lakshmi Venkatraman

Lakshmi VENKATRAMAN | mbilv@nus.edu.sg
Lakshmi joined the Mechanobiology Institute in 2010 after doing her PhD in the Singapore-MIT Alliance. Her PhD research focussed on understanding the dynamics of TGF-Beta 1 activation, using computational modeling and experimental validation. She is currently investigating the effects of liver matrix on liver sinusoidal endothelial cells.
Keywords: thrombospondin, plasmin, matrix signaling, liver fibrosis, fenestration


Neha Bahl

Neha BAHL
Neha graduated from the Indian Institute of Technology Bombay with a Masters degree in Biotechnology. She recently submitted her thesis on the redox regulation of hemoglobin during the innate immune response, and on cross-talk between hemoglobin and coagulation.
Keywords: haemoglobin, innate immunity, molecular modeling, reactive oxygen species.


HUANG Lu
Huang Lu has recently submitted her thesis on Erk signaling. She modeled the effects of scaffolds on the dynamics of Erk pathway activation, and she studied how combinations of Erk drugs might affect cancer evolution.
Keywords: computational modeling, Erk signaling pathway, MP1 scaffold, endosomal trafficking.


CHUA Huey Eng
Huey Eng worked at NTU in Singapore, on a jointly supervised project with Sourav Bhowmick and C. Forbes Dewey Jr. She recently submitted her thesis on computational methods for biochemical network analysis using network topological features and heurestics for efficient prioritization of drug targets.


Anilkumar M. PILLAI
Anil was with our group for a year, after working previously at the Cancer Science Institute of Singapore, and at the Neuroscience Research Center at UNC Chapel Hill.
Keywords: Protein expression and purification, protease-matrix interactions, molecular cloning, mutagenesis.