Meet the Group



Principal investigator


Lisa Tucker-Kellogg

Lisa TUCKER-KELLOGG | Lisa.Tucker-Kellogg@duke-nus.edu.sg
Lisa Tucker-Kellogg moved to the Duke-NUS Graduate Medical School in 2014, to join the Centre for Computational Biology and the Programme in Cancer and Stem Cell Biology. Previously she was an independent postdoctoral fellow at the Mechanobiology Institute and a recipient of the Lee Kuan Yew Postdoctoral Fellowship at the NUS School of Computing. She completed her PhD in computational structural biology at MIT under Tomas Lozano-Perez, Carl Pabo, and Bruce Tidor. She completed her Bachelor's degree in Math and Computer Science summa cum laude at Yale, where she won the A.D. Stanley and the DeForest Prizes in Pure and Applied Mathematics.


Members



Narendra Suhas Jagannathan

Narendra Suhas JAGANNATHAN | suhas@duke-nus.edu.sg
Suhas is a postdoctoral fellow in the lab, coming from the Singapore-MIT Alliance - Computational and systems biology programme. He is working primarily on Markov model analysis of cancer cell phenotype transitions, and he has also worked on metabolomic network modeling, and on development of hybrid methods of computational modeling.


Julia Humphries Jenkins

Julia JENKINS | julia.jenkins@duke-nus.edu.sg
Julia is a postdoctoral fellow from the UK who worked previously on experimental studies of thrombosis. She is currently working on a cell culture model of pressure ulcer injury in differentiated C2C12 muscle cells.


Johannes Antonius Heemskerk

Hans HEEMSKERK | hans.heemskerk@duke-nus.edu.sg
Hans is a post-doctoral fellow studying the regenerative function of muscle stem cells (satellite cells), using genetic labelling with confetti fluorescence. His work is joint with SMART BioSyM and co-supervised by Peter T. C. So.


Nurul Jannah Nasir

Nurul Jannah Binte Mohamed NASIR | nuruljannah.nasir@u.duke.nus.edu
Jannah is a doctoral student studying muscle regeneration, iron, and oxidative stress in pressure ulcers of muscle.


Aadya Sanjay Deshpande

Aadya DESHPANDE | aadya.deshpande@u.duke.nus.edu.sg
Aadya is an MD/PhD student working to understand the speed and dynamics of clonal expansion, when mixed cultures of cancer cells are treated with combinations of anti-cancer drugs. She uses simplified models of cancer evolution, in vitro and in silico.


ALUMNI


Elysia SAPUTRA | elysia.saputra@duke-nus.edu.sg
Elysia was a research assistant in the lab. She worked on computational modeling of cancer cell numbers, subject to synergistic, additive, or antagonistic combinations of anti-cancer drugs. Her modeling used analytical and numerical methods, including stochasitc and deterministic representations.


NIM Tri Hieu |
Nim Tri Hieu completed his high school in Vietnam before joining NTU for undergraduate study in Computer Science. For his doctoral work, he worked on parameter estimation and he modeled the dynamics of Akt activation. He is currently working with Felix Margadant on image analysis.
Keywords: mathematical modeling, cell signaling, reactive oxygen species, cancer, high-performance computing, multiprocessor parallelization, CUDA programming, web service, cloud computing, 3D visualization.


SHI Yuan
Shi Yuan pursued her doctoral degree in the Computational System Biology programme of the Singapore-MIT Alliance from 2007-2012. She got her Master's degree in the field of software engineering and technology in 2006 from Wuhan University, China.
Keywords: apoptosis, reactive oxygen species, cancer, combination therapy, pathway modeling, TRAIL, LY303511.


Akila SURENDRAN |
Akila is finishing some final publications of her doctoral degree in the Singapore-MIT Alliance - Computational and systems biology programme. Her thesis investigated the interplay between RhoA and nitric oxide in regulating cellular tension, and the role of nitric oxide in epithelial migration and epithelial-mesenchymal transition. She completed her undergraduate degree in Biotechnology in Anna University, India.


Lakshmi VENKATRAMAN |
Lakshmi joined the Mechanobiology Institute in 2010 after doing her PhD in the Singapore-MIT Alliance. Her PhD research focussed on understanding the dynamics of TGF-Beta 1 activation, using computational modeling and experimental validation. She is currently investigating the effects of liver matrix on liver sinusoidal endothelial cells.
Keywords: thrombospondin, plasmin, matrix signaling, liver fibrosis, fenestration


Neha BAHL
Neha wrote her thesis on the redox regulation of hemoglobin during the innate immune response, and on cross-talk between hemoglobin and coagulation.
Keywords: haemoglobin, innate immunity, molecular modeling, reactive oxygen species.


TAM Zhiyang |
Zhiyang was a postdoctoral fellow jointly supervised by Peter T. So at the BioSyM Centre of the Singapore-MIT Alliance for Research and Technology. Zhiyang's research designed biologically relevant features for image analysis, built computational models to simulate dynamic morphological change, and adapted methods of statistical machine learning for interpretation of spatiotemporal imaging data.


PANG Long ("Joshua") |
Joshua is an undergraduate researcher studying Rho/Rac signaling during cell spreading. He is focusing on the oscillating pattern found during the protrusion and retraction of cell lamellipodial edges.


HUANG Lu
Huang Lu wrote her thesis on Erk signaling. She modeled the effects of scaffolds on the dynamics of Erk pathway activation, and she studied how combinations of Erk drugs might affect cancer evolution.
Keywords: computational modeling, Erk signaling pathway, MP1 scaffold, endosomal trafficking.