The Tucker-Kellogg Lab at Duke-NUS works on wound healing and computational modeling.
The wound healing side of the lab studies how muscle tissue is injured and repaired,
and our main experimental approaches are microscope imaging of endogenous regeneration,
and molecular assays of cells in vitro. The majority of this work is "wetlab" although
it does include computational image analysis and computational modeling.
The computational modeling side of the lab studies a variety of biological problems
provided by experimental collaborators, as well as the wound healing problems provided
by our own experiments. Computational modeling allows us to take a series of snapshot
measurements, whether from images or molecular concentrations, and infer something
indirectly about the underlying dynamic mechanisms that might give rise to the observed
time-point measurements. This use of modeling to "connect the dots" of experimental
data is particularly relevant to studying the up-and-down dynamics of cell signaling,
or the flow of nutrients through metabolic networks.